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KMID : 1377020160130020200
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Tissue Engineering and Regenerative Medicine
2016 Volume.13 No. 2 p.200 ~ p.209
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Autologous bone marrow mesenchymal cell induced chondrogenesis for the treatment of osteoarthritis of knee
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Huh Sung-Woo
Asode Ananthram Shetty
Kim Jang-Mook
Cho Mi-La
Kim Seon-Ae
Yang Si-Young
Kim Young-Ju
Palaksha Kanive Javaregowda
Choi Nam-Yong
Kang Jin
Kim Seok-Jung
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Abstract
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Healthy and high quality of life has become the main issue with increasing human life span. Many biological treatments for osteoarthritis of the knee have been tried with limited success. We compared data from 7 patients who underwent total knee arthroplasty and 46 patients who underwent autologous bone-marrow mesenchymal cell induced chondrogenesis (MCIC) for osteoarthritis of grade IV of the Kellgren-Lawrence classification and grade IV of modified Outerbridge classification from 50 to 65 years of age. Clinical evaluation of the 2 groups showed significant improvement in the mean telephone Knee Society Scoring system (tKSS)-A (pain) and tKSS-B (function) scores throughout the postoperative follow-up period. There was no difference in the patients’ satisfaction between the 2 groups. MCIC is a treatment option at least for delaying disease progression of osteoarthritis of the knee.
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KEYWORD
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Osteoarthritis, Total knee arthroplasty, Chondrogenesis, Mesenchymal cell induced chondrogenesis, Economy
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